梯队公司/鞘氨醇荧光素/50ug/S-100F-50ug
商品编号：
S-100F-50ug
品牌：
联合碳化
市场价：
¥5860.00
美元价：
2783.50
产品分类：
脂质代谢研究
公司分类：
Lipid_metabolism_study
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
 | CatalogNo.: S-100F MW: 672.81 Description: Echelonoffersauniqueselectionofsphingosineanalogslabeledattheterminusofthealkylchainwithbiotinorfluorescentgroups.Allcompoundsaresynthesizedfromchiralprecursorsandareavailableaslyophilizedpowders. Echelon'salkyl-labeledsphingosinesaresynthesizedwiththenaturalerythrostereochemistryandmaintainsimilarpropertiesassphingosine.Forexample,labeledsphingosinesarephosphorylatedbysphingosinekinases(1&2)andcanbeusedinhighthroughputscreeningapplications.Inaddition,theyinduceaNiemanPicktypeC1diseasecellularphenoypeinRAWmacrophagesinthesamemannerasexogenouslyaddedsphingosine. | ||
StorageSphingosinefluoresceinisrelativelystableatroomtemperatureasasolid.Itisbeststoredasadriedsolid,protectedfromlightat-20ºC.Solutions/emulsionsshouldbekeptat-20ºC.Excitation/Emission494/521nmFeaturedinPublications1)Lloyd-Evans,E.,A.J.Morgan,etal.(2008)."Niemann-PickdiseasetypeC1isasphingosinestoragediseasethatcausesderegulationoflysosomalcalcium."NatMed14(11):1247.2)Xiang,Y.,G.Asmussen,etal.(2009)."Discoveryofnovelsphingosinekinase1inhibitors."BioorgMedChemLett19(21):6119-21. 3)CaliperLifeSciencesApplicationNote205 4)Peest,U.,S.C.Sensken,etal.(2008)."S1P-lyaseindependentclearanceofextracellularsphingosine1-phosphateafterdephosphorylationandcellularuptake."JCellBiochem104(3):756-72. 5)Meissner,A.,J.Yang,etal.(2012)."TumorNecrosisFactor-α-MediatedDownregulationoftheCysticFibrosisTransmembraneConductanceRegulatorDrivesPathologicalSphingosine-1-PhosphateSignalinginaMouseModelofHeartFailure."Circulation125(22):2739-2750. SolubilityMeOH>1mg/ml | |||
